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The phrase "a profound shift from" is correct and usable in written English.
It can be used to describe a significant change or transition from one state, condition, or situation to another.
Example: "The company experienced a profound shift from traditional marketing strategies to digital platforms."
Alternatives: "a significant change from" or "a major transition from".
Exact(5)
Information-Centric Networking (ICN) is one promising architecture paradigm which is a profound shift from address-centric communication model to information-centric one.
The authors write:[T]he focus on preventive services is a profound shift from a reactive system that primarily responds to acute problems and urgent needs to one that helps foster optimal health and well-being.
If Americans turn out to agree with this statement, that would signal a profound shift from embracing the ideal of political equality and joint sacrifice, which has been the basis of our democracy, to accepting the might-is-right form of governance in oligarchic states.
Both co-working and co-living represent a profound shift from the traditional work and home setup.
It's a profound shift from Wall Street capitalism: where a traditional eyewear manufacturer, for example, might pursue profit by going upscale, adorning their glasses with jewels and shiny metals at the largest possible markup, a social business might instead serve the millions in poverty who need but cannot afford eyewear, seeking to decrease costs enough to maintain a profit.
Similar(55)
"Over the last generation there has been a profound shift away from Christian denominational leaders plotting theological agreements and organizations in conference rooms in New York.
But for such an approach to take hold, the conservation movement would have to undergo a profound shift — away from triage mode and toward a more coherent and deliberate plan for global conservation.
Both co-working and co-living represent a profound shift away from how Americans have always operated.
This paper argues that the user-generated content (UGC) created by these consumers represents a profound shift of power from firms to consumers.
(And, for that matter, me kind of hating both sides, as there are plenty of terrible arguments thrown around in the less civil corners of this debate...) I did want to note something that I find kind of fascinating, though, which is that even the arguments for building next-generation colliders reflect a profound shift in attitude from previous generations.
At the heart of this new collective leadership capacity is a profound shift of awareness from ego to eco.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com