These applications, however, require a profound knowledge of miRNA sequences and their genomic organization, which exceeds the currently available information of ∼400 conserved mature CHO miRNA sequences.
Our results suggest that mutation rate variation across the genome has a profound influence on patterns of sequence evolution in Arabidopsis, as both silent and nonsynonymous polymorphism as well as nonsynonymous divergence mainly correlates with synonymous divergence.
Total peptide coverage corresponded to 47% of the predicted peptide sequence with a ProFound expectation score of 2.5 × 10-6 [ 11].
Indeed, similar to sir2Δ, cells lacking Clr3 and mutant for Clr6 show a profound loss of silencing of subtelomeric sequences (Hansen et al, 2006) and at centromeres, a redundant role for Clr3 in maintenance of H3K9me2 heterochromatin is revealed in cells additionally mutated for the RNAi pathway (Yamada et al, 2005).
It was our intention to explain to the reader that a profound assessment of a proposed myocardial edema by modern sequences, such as a "STIR" sequence, a special T2-weighted image, must be followed by a thorough analysis.
The analyzed data set comprises more than 650 mitochondrial genomes that have been chosen to represent a profound sample of the phylogenetic as well as sequence diversity.
Since recombining fragments among aligned codon sequences have a profound effect on the detection of the positively selective evidence [ 29], we first tested for recombination signals between sequences in the alignment of orthologous genes.
It is now well known that the position of the nucleosome along a particular sequence of DNA has profound effects on its accessibility for all DNA processes such as transcription regulation, recombination, and repair [ 1- 3].
Since AT-repeats are also the most abundant 5-mers in the P. falciparum genome, comprising 3.4% and 10.7% of gene and intergenic genome sequence, respectively, these sequences may have a profound effect on the nucleosome landscape of this parasite.
I have a profound loathing of them.
"He has a profound love of America".
