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In marked contrast, when cell lines were preincubated with 10 ng/ml TRAIL for 30 min before the treatment with increasing concentrations of doxorubicin a profound sensitization and strongly increased cell death induction was seen in all cell lines.
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ATRi by VE-822 resulted in profound sensitization of PDAC cells to radiotherapy both in vitro and in xenografts, to the extent that the combination of VE-822 and XRT prevented MiaPaCa-2 tumor regrowth in some mice.
Importantly, we also showed that elimination of endogenous Abcc10 has a profound effect on tumour sensitization to taxanes and overall survival.
The association between CFS and TMD pain duration was exceptionally high, suggesting a more profound central sensitization [49].
From the study, it may be concluded that sensitization time has a profound influence on all the photovoltaic parameters, thus, effecting the photoconversion efficiency of these cells.
In line with this idea, we have seen that primary organoids are exquisitely sensitive to TNF α and chemotherapeutic drugs, reflecting the situation in vivo, whereas the colorectal tumor cell line Caco-2 showed a profound resistance to chemotherapy, and only responded moderately to TNF α after sensitization by ActD.
A profound stillness descends.
What a profound loss.
This is a profound loss.
That's a profound contribution".
It's a profound collection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com