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The profound requirement for LTB4 highlights the importance of this lipid mediator of inflammation in the orchestrated, yet poorly understood, process of arthritis.
Considering the profound requirement of NGF for nonpeptidergic nociceptor gene expression, one possibility is that NGF promotes expression of Runx1, Cbfb, or both, thereby enabling Runx1/CBFβ complex formation, stabilization and function, and thus initiation of the nonpeptidergic nociceptor fate.
One had best face up to the profound requirements of what children require before you have them or the kids will be awful and you and your mate stand a fair chance of being pretty dreadful too.
There are profound requirements implicit in the very nature of universal wholeness that requires an elaboration of self-similar requirements nested within it in discrete subsumed stages.
"This has induced a profound impact on marketing requirements, where I'm forced to constantly remain in contact and provide continuous support by aligning my marketing strategy with current trends". They share more content on social media.
There may therefore be a profound species difference in the requirement for tankyrase during mitosis.
For the successful realisation in practice, a profound knowledge about the mechanical requirements of products, the mechanical properties of the plants as well as the related environmental aspects is necessary.
P. gingivalis has an essential requirement for haem [3] which has a profound influence on its virulence properties [4], [5].
For many people looking for work, however, the technological requirements of the modern job hunt present a profound hurdle.
A profound stillness descends.
What a profound loss.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com