The phrase "a profound reduction of" is correct and usable in written English.
It can be used when discussing a significant decrease in quantity, quality, or intensity of something.
Example: "The study revealed a profound reduction of air pollution levels in the city after the new regulations were implemented."
Alternatives: "a significant decrease in" or "a substantial decline in".
The benefits of the passive design over an active exoskeleton are quite significant due to a profound reduction of weight and complexity from motors and software — this one just uses simple physics and mechanics.
Most interestingly, a profound reduction of tumor load and prolonged survival of animals was observed upon BV6 in vivo treatment alone which was even more pronounced in combination with multidrug chemotherapy.
The results show a profound reduction of cytokines such as IFN-γ, TNF-alpha, IL-12.
Western blot confirmed a profound reduction of the Rieske protein in both ρ° cell types (Figure 2B).
Torpor is associated with a profound reduction of energy expenditure to as little as 3% of the euthermic rates at ambient temperature [1].
As is shown in Fig. 2C and Fig. S1, lapatinib consistently induced a profound reduction of TS, TK1, DHFR, or RRM2 mRNA in a dose-dependent manner as compared to gefitinib.
Ultimately, pain and disability associated with the disease lead to a loss of functional independence and a profound reduction in quality-of-life.
This resulted in a profound reduction in growth of the cancer cells.
In this model, they observed a profound reduction in expression of CXCL8 that attenuated tumor associated angiogenesis.
In EDIC, metabolic memory accounted for a profound reduction in risk of further disease progression that continues to be evident after more than a decade of follow-up.
Interestingly, although interference is specific at the level of mRNA, silencing of one subunit leads to a profound reduction in the level of protein for both subunits, suggesting that survival, or perhaps synthesis, of each subunit depends upon the presence of the other.
