The phrase "a profound negative impact" is correct and usable in written English.
It can be used when discussing the significant adverse effects of an action, event, or situation.
Example: "The new policy has had a profound negative impact on employee morale and productivity."
Alternatives: "a significant detrimental effect" or "a serious adverse influence."
The report's recommendations include: The government should take action to discourage schools from setting children by ability, particularly at primary level, because of evidence that it could have a profound negative impact on pupils' future social mobility.
"The global credit crisis has had a profound negative impact on what was already a weakening and very fragile global economy," Jeffrey M. Fettig, the chairman and chief executive, said in a statement.
The $5.6bn acquisition of the Wall Street Journal in 2007, at a steep premium to its market value, happened despite the recognition by News Corp's executives that the deal would have a profound negative impact on News Corp's shares – and despite the fact that the Journal would shortly be worth only a fraction of what the company paid for it.
Treating APIs as copyrightable would have a profound negative impact on interoperability, and, therefore, innovation.
Lymphedema following treatment for breast cancer can be an irreversible condition with a profound negative impact on quality of life.
Symptoms have a profound negative impact on quality of life and are associated with increased health care utilization.
Moreover, a study which included a female rat model that exerted the metabolic and hormonal characteristics of women with hyperandrogenemia, suggested that dietary glycotoxins, in combination with increased androgen exposure, exert a more profound negative impact on the kidney.
Our results do not exclude a more profound negative impact of individualized treatment compared to standard, possibly caused by higher doses and extended treatment duration in the individualized group.
We further emphasized that IBS, from a medical point of view, is not a dangerous disorder, but that it has profound negative impact on quality of life.
"We believe that the Arctic refuge should be preserved and that the budgetary effects of oil leases in the refuge are incidental when considering the profound negative impact of drilling in the Arctic refuge".
It is the intensity of the anxiety experienced, the wider range of feared social situations, and the profound negative impact on functioning that sets SAD apart from milder instances of social apprehension.
