The phrase "a profound negative effect" is correct and usable in written English.
It can be used when discussing the significant adverse consequences of an action, event, or situation.
Example: "The new policy has had a profound negative effect on employee morale and productivity."
Alternatives: "a significant adverse impact" or "a deep detrimental effect."
Urbanization and agricultural intensification resulting in habitat loss is having a profound negative effect on grassland and farmland birds worldwide.
Furthermore, some common forest management practices can have a profound negative effect on cavity quantity and quality.
The problem with this theory was that ACEs had a profound negative effect on adult health even when those behaviors weren't evident.
This guessing game, this internal dialogue in the face of ambiguous discrimination, is called attributional ambiguity, and it can have a profound negative effect on performance by not letting you concentrate on the task at hand.
"Not only does this threaten the viability of Philadelphia's gay pride organization, it will have a profound negative effect on the myriad of community non-profits that depend on our events," reads the announcement.
It added that "since 2010 the downgrading of youth policy and cuts to local government services are having a profound negative effect".
We found that ATM inhibition had a more profound negative effect on Tap63α activation than c-Abl (Suppl. Fig. 1), suggesting that ATM might also be regulating doxo-induced TAp63α activation independent of c-Abl in oocytes.
We also need to consider the suffering that is being endured by these high levels of joblessness, including the profound negative effect on the families of the unemployed.
In her book Thrive, Arianna Huffington outlines a number of scientific studies that confirm the profound negative effects that overwork, burnout and sleep deprivation have on practically every part of our mental and physical health and performance.
And in Thrive, I quote a large number of scientific studies that confirm the profound negative effects that overwork, burnout, and sleep deprivation have on practically every part of our mental and physical health and performance.
The council cited negative attention "across national and social media" as well as potentially "profound, negative effects" on the local business community lasting for years.
