The phrase "a profound issue" is correct and usable in written English.
It can be used when discussing a topic that is deep, significant, or has serious implications.
Example: "Climate change is a profound issue that affects every aspect of our lives and future generations."
Alternatives: "a significant matter" or "a deep concern".
A profound issue is at stake here.
The Noel Canning case, for example, raises a profound issue in constitutional law.
This is a profound issue of daily consequence that technological advances have wrought.
But he cannot avoid raising the question of whether the problem of Islamism is inherent in Islam itself -- a profound issue on which this book does not dwell.
"Quickly Vetted, Treatment Is Offered to Cancer Patients" ("The Evidence Gap" series, front page, Oct. 27) explores a profound issue in cancer therapy: development of new treatments versus safety and comfort of the status quo.
"The small percentage of our population in uniform, and with other parts of our society not involved, is a profound issue," said Senator Jack Reed, a Rhode Island Democrat and alumnus of West Point who served in the 82nd Airborne Division.
How the federal bench is shaped in the next four or eight years, scholars say, could have a profound effect on issues like affirmative action, abortion rights and the lengths to which the government may go in aiding parochial schools.
Failing to consider these issues has a profound effect on the number and identity of genes designated as differentially expressed.
How the federal bench is shaped in the next four or eight years, scholars say, could have a profound effect on such issues as the constitutionality of affirmative action programs, the lengths to which the government may go in aiding parochial schools and how much states may be permitted to limit abortion rights.
How the federal bench is shaped in the next four or eight years, scholars say, could have a profound effect on such issues as the extent of federal power in relation to the states, the constitutionality of affirmative action programs, the lengths to which the government may go in aiding parochial school students and how much states may be permitted to limit abortion rights.
Being weaned on such issues has had a profound effect.
