The phrase "a profound fall in" is correct and usable in written English.
It can be used to describe a significant decrease in a particular metric or value, often in contexts such as economics, health, or environmental studies.
Example: "The report indicated a profound fall in the country's GDP over the last quarter."
Alternatives: "a significant drop in" or "a dramatic decline in".
Pamidronate induced a profound fall in bone resorption with a maximal effect within the first month after therapy.
In anaesthetized rats with denervated peripheral chemoreceptors, acute inhibition of 50% of the C1 neuronal population resulted in ∼50% reduction in renal sympathetic nerve activity and a profound fall in arterial blood pressure (by ∼25 mmHg).
Administration of SNAP produced a profound fall in BP in both [Pyr]apelin-13 and MM07-treated groups; however, although cardiac output was significantly increased in response to SNAP in the MM07 group, it was significantly reduced in the [Pyr]apelin-13 group.
It is probably acquired far earlier, and what it leads to is a profound falling in love with the imagination, our own included, that is set off by words and make-belief worlds on a page.
Twelve-month Greek yields plunged more than a third and there was a smaller but still profound fall in the cost of insuring against default.
Although to quote Paul Simon there had been 'hints and allegations' that high-dose corticosteroids can reduce IgG synthesis [ 2], neither the authors of the Ginzler study nor any colleagues I have spoken to in rheumatology or nephrology could recall seeing anything like these very profound falls in IgG levels within a fortnight of starting steroids and mycophenolate.
A profound shadow falls on the earth.
A profound silence fell, broken only by spoons scraping on plates.
Of particular note: this fall has seen a profound increase in traffic congestion, even when adjusted for seasonal holiday shoping traffic.
Change-in-support (CIS) balance reactions, which involve very rapid stepping or grasping movements of the limbs, play a critical role in preventing falls; hence, a training program that improves ability to execute effective CIS reactions could potentially have a profound effect in reducing risk of falling.
We propose to use a novel water-based training program which includes specific perturbation exercises that will target the stepping responses that could potentially have a profound effect in reducing risk of falling.
