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Pamidronate induced a profound fall in bone resorption with a maximal effect within the first month after therapy.
In anaesthetized rats with denervated peripheral chemoreceptors, acute inhibition of 50% of the C1 neuronal population resulted in ∼50% reduction in renal sympathetic nerve activity and a profound fall in arterial blood pressure (by ∼25 mmHg).
Administration of SNAP produced a profound fall in BP in both [Pyr]apelin-13 and MM07-treated groups; however, although cardiac output was significantly increased in response to SNAP in the MM07 group, it was significantly reduced in the [Pyr]apelin-13 group.
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It is probably acquired far earlier, and what it leads to is a profound falling in love with the imagination, our own included, that is set off by words and make-belief worlds on a page.
Twelve-month Greek yields plunged more than a third and there was a smaller but still profound fall in the cost of insuring against default.
A profound shadow falls on the earth.
A profound silence fell, broken only by spoons scraping on plates.
When they crossed the bridge and their armored cars were rolling up Narodní a profound silence fell over the whole city.
Although to quote Paul Simon there had been 'hints and allegations' that high-dose corticosteroids can reduce IgG synthesis [ 2], neither the authors of the Ginzler study nor any colleagues I have spoken to in rheumatology or nephrology could recall seeing anything like these very profound falls in IgG levels within a fortnight of starting steroids and mycophenolate.
The game's attempt to make its bloodshed profound falls flat.
Brain extracellular [Ca2+] is dynamic and decreases as neuronal activity increases- moderate decreases in [Ca2+]o accompany bursts of synaptic activity [61] while profound falls to ∼0.1 mM result from focal brain trauma or ischemia [62], [63].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com