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This had a profound effects on American society, as it both frightened Americans and undermined the notion of American exceptionalsim.
Induced expression of a transgene inside of the intercalary heterochromatin leads to changes in replication timing, polytenization level, and chromatin structure in a broad area around integration site (Koryakov et al. 2012) indicating that the transcription in the intercalary heterochromatin can have a profound effects on a local genomic environment.
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The experience had a profound effect.
They had a profound effect".
" It had a profound effect," he said.
It had a profound effect on me".
Losing population can have a profound effect on a place.
Becoming a father had a profound effect on me.
"The layoff has had a profound effect on me.
The differences do not always have a profound effect.
This experience had a profound effect on her.
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