Sentence examples for a profound disruption from inspiring English sources

Renal cell carcinoma (RCC) is characterized by a profound disruption of proapoptotic signaling networks leading to chemo- and radioresistance.

Hedging against the risk of a profound disruption helps explain the premium being paid for these low-yielding assets.

When secularisation was implemented in the developing world, it was experienced as a profound disruption – just as it had originally been in Europe.

The sharing economy entails a profound disruption of current modes of production; it could destroy small-scale retail enterprises and it could diminish, rather than enrich, our culture.

By requiring that the procedures and the drugs create a profound disruption, the statue requires more than that the acts "forcibly separate" or "rend" the senses or personality.

"By requiring that the procedures and the drugs create a profound disruption, the statute requires more than that the acts forcibly separate or rend the sense or personality," it said.

The results obtained here indicate that STAT6-dependent reduction of lethality compromises more than the IgE-mast cell axis, and must be related with a more profound disruption of IL-4-driven Th2 response in the CF mouse but also affecting CF lung disease in humans.

CMP caused a more profound disruption of the early genotropic output from BDNF compared to MeCh stimulation at multiple levels of investigation (Figure 5 6).

Everyone knows that we live in a moment of profound disruption.

Critical illness is exemplified by a state of profound disruption in normal homeostatic mechanisms.

However our results reveal a much more profound disruption of the whole contact site with actin rich protrusions providing very few points of contact for receptor interactions between the two cells which would impair TCR coalescence to form the cSMAC.