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The phrase "a profound difference" is correct and usable in written English.
It can be used to emphasize a significant or deep distinction between two or more things.
Example: "There is a profound difference between merely existing and truly living a fulfilling life."
Alternatives: "a significant difference" or "a deep contrast".
Exact(57)
It made a profound difference for me.
There is a profound difference.
It makes a profound difference".
"That kind of generosity can make a profound difference".
But each of these changes made a profound difference.
Compounding this divergence was a profound difference in style.
Giving them constitutional power will make a profound difference.
The interventions are simple but can make a profound difference.
"We have a profound difference of opinion," he said.
"I believe it will make a profound difference".
But Clinton's allies argue her advocacy on women's issues has made a profound difference.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com