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Growth suppression in vivo was associated with loss of D-cyclin expression, hypophosphorylation of Rb, a profound decrease in cell proliferation as measured by Ki67, and induction of apoptosis as measured by TUNEL and cleaved PARP (Figure 4A and 4C).
Second, we observed a profound decrease in cell proliferation as measured by staining for the phosphorylated Histone H3 (HH3, Figures 2C & 2D; group effect: F3,11 = 4.01, p<0.04).
Similar(58)
For instance, forcing fatty acid synthesis with citrate produced a greater increase in the formation of SFA in SCD1-deficient when compared to normal cells and a more profound decrease in cell proliferation.
In this group of patients, fulvestrant inhibits tumour cell proliferation associated with a profound decrease in immunocytochemically detectable ER protein (Defriend et al, 1994; Robertson et al, 2001).
A profound decrease in the number of light-responsive ganglion cells was observed during degeneration, culminating in retinas without detectable light responses by P550.
Infection of both Caco-2 and LS174T cells with specific lentiviruses resulted in a profound decrease in Bim, resp.
This was associated with an increase in cell packing and a decrease in cell proliferation.
Furthermore, resveratrol exerted antiapoptotic effects that were not associated with a decrease in cell proliferation.
Nevertheless, the same trend regarding a decrease in cell proliferation could be observed.
Qualitative analysis of cell proliferation illustrated a decrease in cell proliferation with increasing concentrations of vorinostat.
It may cause a decrease in cell proliferation.
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