Thus, in animals, the main event leading to diaphragmatic hernia has its origins in the destruction of the main mesenchyme primordia from the profound area of the pleuroperitoneal fold (PPF).
But leadership-development research we've conducted with data from thousands of executives from all over the world points unmistakably to the conclusion that it's the presence of a few truly profound areas of strength that distinguishes us in an organization — the things you're so good at that people forgive (or don't even think about) your weaknesses.
In a Sunday Times article Cameron said it "would be insulting the public's intelligence to pretend there aren't profound areas of disagreement" between the Conservatives and the Lib Dems, citing Lords reform and Europe in particular.
Writing in the Sunday Times (paywall), the prime minister acknowledged there were "profound areas of disagreement" between the Liberal Democrats and members of the Conservative party, 91 of whom rebelled last week against a reform package for the upper house championed by Nick Clegg.
We did this by first generating xenografts that contained profound areas of hypoxia, and produced lung metastases.
One of the largest human genes, DKFZp686H, is located at 11q25, close to a common fragile site – an area of profound genomic instability (Smith et al, 2006).
Something similar happens to musicians who find a "groove" that allows them to slip behind the musical form and areas where a profound sense of harmony and moments of grace are waiting to be found.
In cases 2 and 3 the cortical areas displayed a profound depletion of the neurons [ 13, 25] and the residual neurons were identified as finely granulated single cells or small groups of cells that were detectable by using the NeuN antibody.
I have certainly found - and some of my colleagues have too - that while you might not necessarily feel like you experience significant stress at the time, on completing a tour and leaving an operational area there is a profound experience of what I describe as 'going cold turkey', when you quite literally 'come down' from the effects of living on high adrenaline for many months at a time.
He found work as a signwriter, but the family lived in profound poverty in an area of inner Manchester that had scarcely improved since caricatured by Mrs Gaskell in her mid-19th-century novel Mary Barton: A Tale of Manchester Life.
