Sentence examples for a profound alteration of from inspiring English sources

Paget Disease of the bone is a metabolic disorder which leads to a profound alteration of the bone's architecture.

This psychedelic substance then crosses the blood-brain barrier and binds to a specific serotonin receptor known as 5-HT2A, creating a profound alteration of consciousness that has been described as a mystical event, a spiritual journey or simply a "trip".

Therefore, the antimalarial activity of MeSter would directly depend on a profound alteration of membrane fluidity.

When miR-221 and miR-222 were expressed in myotubes undergoing maturation, a profound alteration of myofibrillar organization was observed.

Additional removal of helix 8 (RhΔctΔH8 mutant) led to impaired transport of the receptor and a profound alteration of the rhabdomeric structure (Fig. 3).

In our study, overexpression of miR-155 induces indeed a profound alteration of mRNA profiles associated with an over-representation of miRNAs predicted targets among the down-regulated transcripts.

Our data provide evidence of a profound alteration in the distribution of subsets of DCs, especially pDCs, in the peripheral blood of CVID patients.

Atherosclerotic lesions are characterized by a profound alteration in the architecture of the arterial intima, with a marked increase of fibronectin (FN) and the appearance of the alternatively spliced FN variant containing the extra domain A (EDA).

During diabetes a profound alteration in the concentration and composition of lipid occurs [ 3].

During diabetes, a profound alteration in the concentration and composition of lipids occurs.

This state of development required a profound alteration in the genetic template to produce short pelvic blades, a forward-pointing big toe (adducted hallux), and other bipedal traits.