The phrase "a profound affinity" is correct and usable in written English.
It can be used to describe a deep and strong connection or bond between people, ideas, or things.
Example: "The artist felt a profound affinity for nature, which inspired much of her work."
Alternatives: "a deep connection" or "a strong bond".
"It will, above all, be those who sense the profound affinity that exists between the film medium and a desire to understand people".
Recognizing his profound affinity with the Venetian master, he copied "Europa" and other works in a virtuoso act of homage.
A marvelous interpretation of the "Goldberg" Variations at Symphony Space in 2008 revealed Mr. Denk's profound affinity with Bach.
Both Ms. Chapman and Mr. Dylan have just released strong new albums that, heard together, demonstrate the profound affinity between their sensibilities.
(Andriessen's profound affinity with Stravinsky has produced, as well as refractions of Igor's techniques in his own idiom, one of the best books ever written about the Russian composer, The Apollonian Clockwork).
It is this profound affinity that Ara H. Merjian examines in his handsomely produced study of de Chirico's metaphysical painting, a term that encompasses the artist's enigmatic cityscapes produced primarily in Paris between 1911 and 1915.
Not until the past decade have scholars in Germany and America demolished this notion, by tracing the profound affinities between Heidegger's thought and his reactionary milieu.
But mere ambiguity is not enough to explain the efficaciousness of these forms, which suggest profound affinities among the psychological, the natural and the creative.
We show that type II binding can have a profound influence on binding affinity for CYP3A4, and the difference in binding affinity can be as high as 1200-fold.
