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The phrase "a profile of him" is correct and usable in written English.
You can use it when referring to a description or summary of someone's characteristics, background, or achievements.
Example: "The article provides a detailed profile of him, highlighting his contributions to the field of science."
Alternatives: "a depiction of him" or "a summary of his background."
Exact(60)
(Jennifer Kahn wrote a Profile of him in 2011).
The mayor's press office encouraged him to let the magazine Boston do a profile of him.
A "CBS Morning News" team was working on a profile of him.
I read a profile of him in the New Yorker a few months back.
I was working on a Profile of him for this magazine.
(Of course, a quick search revealed that the magazine published a Profile of him, in 1969).
(Joan Acocella wrote a Profile of him for The New Yorker).
I had been commissioned by the Guardian Review to write a profile of him.
Why not just go off somewhere — somewhere other than Outward Bound — with Euell Gibbons, and do a Profile of him?
A profile of him published in The New York Times in 2000 described him as "a loud, throbbing administrative pain".
Steyer, for example, cooperated with the New Yorker when it wrote a profile of him last year.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com