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Lixisenatide is a novel GLP-1RA that shares the main features of these agents but has a profile of action that appears intermediate between short-acting exenatide and longer-acting agents (13 , 15.
In the chronic inflammatory pain model – monoarthritis – KTP-NH2 at the dose of 32.3 mg·kg−1 significantly increased the threshold response, with a profile of action similar to that obtained with acute stimulus.
Interestingly, vascular responses after controlled exposure of diesel exhaust in humans show a profile of action similar to that seen in our in vitro study (Mills et al. 2005).
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Accordingly, a profile of actions can be defined for all players as p(t)=(p 1 t),p 2 t),…,p N (t)).
AT is a well-explored mediator with a dual profile of action including its anti-inflammatory as well as anticoagulant effects.
Topiramate, through a broad profile of action, might act at different levels: reducing nociceptive transmission through trigeminovascular modulation, and inhibiting cortical spreading depression [20, 21].
The disagreement with the reports documenting a positive profile of action for metformin could be explained on the basis of some methodological aspects that distinguish our study from the previous ones.
This observation presents a profile of field where action has the features 'verbal: constitutive'; sphere is 'specialised' (as in Hasan [1999]: 311).
However, bezafibrate has a unique characteristic profile of action since it activates all three PPAR subtypes (alpha, gamma and delta) at comparable doses.
With the once-daily GLP-1 receptor agonist liraglutide, which offers a 24-h profile of action, the placebo-adjusted reduction in A1C was 1.7% after 14 weeks of treatment (24).
However, bezafibrate, in comparison with other fibrates has a unique characteristic profile of action since it activates all three PPAR subtypes (alpha, gamma and delta) at comparable doses [ 1- 5].
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CEO of Professional Science Editing for Scientists @ prosciediting.com