Altogether, these relationships lead us to ask whether calpain cleavage of SMN is a physiologically productive event, leading to proper SMN function, versus a pathological result of aberrant calpain activation.
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As a young adult, K believes that divorce can be a healthy and productive event for a family.
For elementary school teachers, a parent conference is a normal and often productive event.
Thus, topoisomer s 1 disappears more slowly because it spends more time undergoing repetitive cycles of cleavage and ligation before a productive unwinding event occurs.
The disruption of the PA domain 2 receptor interaction in more than one PA63 receptor complex may be needed to induce similar rearrangements in neighboring monomers before a productive insertion event can occur.
By allowing hetero-oligomers of wild-type and G342A PA63 monomers to form from an equimolar mixture of the proteins, we then addressed whether each monomer within a PA63 oligomer must reach its pH threshold before a productive insertion event can occur.
A merit of the single-molecule approach is that we could characterize these rare productive events (e.g., Figure 2B C) independently of the excess of non-productive events.
This means that only the "productive" events of transcription are considered.
According to productive events the median elongating RNA pol II density of 0.078 molecules/kb corresponds to an average of 0.096 molecules/gene.
In the productive events, Arp2/3 complex and diVCA release were not simultaneous.
