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Our main aim is to derive a model that highlights potentially problematic series early on in the drug discovery process and in this context one false positive such as compound 663916 which is a very close analogue to the moderately cytotoxic compound 664633 would not necessarily indicate failure of the model.
A problematic dilution series (ath-miR405a) was identified with low R and β1 values, which is most likely attributed to pipetting errors.
These made Richard's work more usable in unbalanced and waveguide formats by eliminating the problematic series connected elements, but it was some time before Kuroda's Japanese work became widely known in the English speaking world.
"The series was a tough series.
While these 80s movies are almost unavoidably a problematic fave, George Lucas and Steven Spielberg's action serials inspired series has always been a cooler sibling to their Star Wars franchise.
He's a problematic interviewee.
Distribution is a problematic word.
But it was a problematic notion.
It proves to be a problematic oddity.
"Goon" is a problematic word, I grant.
It's just a problematic thing".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com