The phrase "a problematic compound" is correct and usable in written English.
It can be used to describe a compound that presents issues or challenges, often in a scientific or linguistic context.
Example: "The researchers identified a problematic compound in the sample that could affect the results of the experiment."
Alternatives: "a troublesome compound" or "a challenging compound".
But when Sultan threatened to pull his human rights team in protest, the separation was confined to the problematic compound.
These data show that there is a fairly low percentage of potentially problematic compounds in screening libraries.
The first step in creating a diverse library is to remove all the potentially problematic compounds.
On the other hand, the structure and composition of its unusually thick cell wall that is formed as a response to the high salt concentrations might limit the diffusion of problematic compounds before they even reach the plasma membrane.
Other potential problematic compounds are: ethylene, diborane and ethane (in this order).
Fining agents are used to remove these problematic compounds prior to bottling to save time, expensive filter membranes, and the winemaker's sanity- because worrying about hazes forming post-bottling is enough to give anyone nightmares.
A set of 5 SMARTS-based flags is also available to provide warnings on potentially problematic compounds that typically contain undesired substructure patterns.
These average values nevertheless mask some differences between providers, with some of them having up to 20%percentt of potentially problematic compounds.
In particular, failure to recognize and remove promiscuous and similarly problematic compounds can easily lead to expensive false trails, wasted resources, and flawed conclusions.
We note that the implemented real-time fluorescence monitoring (kinetic read) to derive reaction rates also makes the TAMRA/BHQ-2 assay less susceptible to variations in the screening equipment and permits facile discovery of problematic compounds which may interfere with detection [30].
