Sentence examples for a problem of substantial from inspiring English sources

The bacteria cause severe infections after surgical treatments and infect implanted material, thereby posing a problem of substantial clinical relevance (20, 26, 27 ).

We also identified a problem of substantial positive bias in harm rate estimates where there are high levels of inter-patient variation.

Lack of comprehensive gender analysis and gender-disaggregated data - Even if gender disparities and inequalities in the BiH society are recognised, a common opinion is that gender-based discrimination does not constitute a problem of substantial magnitude.

Mr Shields told BBC Radio Ulster he found the level of failures in registration "surprising" and added that prior to the report, there had been no anecdotal evidence to suggest that there was "a problem of any substantial size", He pointed to the assembly and council elections in May 2011, when about 668,000 people turned out to vote in Northern Ireland.

Background: The quality of medication use in older adults is a recurring problem of substantial concern.

But it seems unlikely that this approach will resolve the core problem of substantial pricing uncertainty.

The problem of substantial molecular evolutionary rate heterogeneity does not appear to be present in the Ovalentaria AHE dataset.

In order to avoid the problem of substantial variability in published estimates of body mass and length, we pooled studied taxa into appropriate weight/length categories (Table 1).

The problem of prescribing errors in hospitals is substantial and not solely a problem of the most junior medical prescribers, particularly for those errors most likely to cause significant patient harm.

Numerical results demonstrate that the method converges and show its capability to handle a number of flow problems of substantial current interest.

The magnitude of such a problem is substantial if one considers that in yeast alone there are ∼6000 genes potentially regulated by up to ∼400 proteins, thereby producing ∼6000×2400 possible bound/unbound states.