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The phrase "a problem of major concern" is correct and usable in written English.
It can be used when discussing an issue that is significant or serious enough to warrant attention or action.
Example: "The rising levels of pollution in our city represent a problem of major concern for public health."
Alternatives: "a significant issue" or "a critical problem".
Exact(1)
The in-service brittle fracture of a structural component of a nuclear power plant (NPP) is a problem of major concern in engineering.
Similar(59)
Other problems of major concern included social exclusion, violence, children's welfare, and financial difficulties.
This problem is of major concern when several different NB cell lines have to be compared in in vitro studies.
Further, fiction-related problems are of major concern in effective maintenance as friction-related problems cost industries over $1 billion per annum.
The findings revealed that obesity and other weight problems are of major concern in Irish children, with girls being more affected.
The unmanaged urbanization is also a source of major concern.
Often occurring wound dehiscence is also a problem in sites where esthetics is of major concern.
That would be less of a problem than the false positives, but still of major concern, those officials said, because it signals that the lab is unable to perform its job.
Bisphenol A (BPA) is one plastic contaminant of major concern.
The latter is of major concern since it may result in lifelong problems.
This approach can provide a solution to the problem of nocturnal hypoglycemia, a major concern of patients with diabetes.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com