The phrase "a problem of great" is not complete and lacks clarity in written English.
It can be used when discussing significant issues or challenges, but it needs to be followed by a noun to specify what kind of problem is being referred to.
Example: "This is a problem of great importance that needs immediate attention."
Alternatives: "a significant issue" or "a major concern".
The disposition of energy in the solar corona has always been a problem of great interest.
Physics has played a useful role in tackling a problem of great technical importance in biology.
Ensuring Safe Surgery is a problem of great interest in public health.
The aging of young investigators is a problem of great importance, both for science and for scientists.
Wind rain induced vibration of cables of cable-stayed bridges is presently a problem of great concern.
Predicting protein sequences that fold into specific native three-dimensional structures is a problem of great potential complexity.
But focusing on the absurdity of the primary calendar obscures a problem of greater significance: not all voters are equal.
Furthermore, the rate of TB-HIV co-infection in our study alone over a 1.5 year period (n = 48) does not correlate well with the rate of HIV-TB co-infection in all of Bolivia reported in 2013 (n = 170) [ 1]; this data raises concern that this is a problem of greater magnitude than is currently appreciated.
A problem of even greater importance is that the FDA routinely approves medications and medical devices that provide only marginal benefit at exorbitant costs, even when it has all relevant data.
Motivation: While phylogenetic analyses of datasets containing 1000 5000 sequences are challenging for existing methods, the estimation of substantially larger phylogenies poses a problem of much greater complexity and scale.
Some commentators see in such figures a social problem of great importance and promote various programs of educational reform intended to produce higher levels of literacy.
