The phrase "a problem of alignment" is correct and usable in written English.
It can be used when discussing issues related to coordination, agreement, or positioning in various contexts, such as business, technology, or personal relationships.
Example: "The team is facing a problem of alignment in their goals, which is affecting their overall productivity."
Alternatives: "an issue of alignment" or "a matter of alignment".
By and large, existing methods treat the interpretation of functional data as a classification problem (between bound and unbound DNA), and the analysis of comparative data as a problem of local alignment (to recover phylogenetic footprints of presumably functional elements).
Another caveat is that there is a potential problem of alignment reliability especially for noncoding regions.
The problem of estimating the vehicle movements became a problem of range scan alignment.
Although these conventional studies solve the problem of self-alignment of a part with gripper, the problem of alignment with other part is not considered.
It is designed to overcome the problem of alignment, the flow being aligned with the grid.
To accomplish the first aim, we formulated it as a problem of finding the optimal local alignment of two sequences containing one unaligned and unpenalized region/gap (corresponding to one SV) between two aligned regions.
The problem of alignment can be circumvented by choosing a mesh periodicity which is smaller than the widths of the contact pad on the top of the LEDs (100 μm in our design).
Alignment based methods are difficult to apply at the whole genome level due to the problem of alignment.
The problem of alignment errors arises especially on large-scale phylogenies with many taxa that span a broad divergence range [10], where many homologies lie in the twilight-zone of sequence alignments [11].
There are several possible ways to resolve the problem of alignment uncertainty: 1) explore the effect of different alignment strategies, 2) removal of uncertain regions and/or 3) include protein coding genes where homologous alignment may be more objective by using the more conserved amino acid sequences.
