The phrase "a problem in understanding" is correct and usable in written English.
It can be used when discussing difficulties or challenges related to comprehension or grasping a concept.
Example: "There seems to be a problem in understanding the instructions provided, as several team members have asked for clarification."
Alternatives: "an issue with comprehension" or "a difficulty in grasping".
This student might have a problem in understanding the distributive property of exponents.
There is a problem in understanding quite what a 'synthesizing category' or 'covering value' is.
Any potential problem was then also assigned a code as to whether it was a confirmed problem (as opposed to a pause by the patient that did not mean there was a problem in understanding), and whether or not a change could be made to the survey to resolve the problem.
The vague expression pattern may not be a problem in understanding biological nature of gene-expression signature in a set of multiple samples as long as a subset of samples presents distinct expression pattern of the signature.
Motivation: A common problem in understanding a biochemical system is to infer its correct structure or topology.
Prediction of bed load flux remains a significant problem in understanding braided river morphodynamics for geomorphic and engineering applications.
The question is: why? "A major problem in understanding what happened when modern humans appeared in Europe has concerned the dates for our arrival," said Professor Chris Stringer, of the Natural History Museum, London.
A key problem in understanding valley evolution in alpine landscapes has been the lack of an independent timescale against which to measure morphological change.
There is a major problem in understanding how extremely subtle sequence changes can lead to profound and often unexpected differences in self-assembly behavior.
Revealing protein-DNA interactions is a key problem in understanding transcriptional regulation at mechanistic level.
The origin of the precursors of endothelial cells (ECs) has created controversy in understanding tumor growth related vasculogenesis, whereas the illusive origin of HSCs had been a daunting problem in understanding embryonal development.
