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Some have suggested that since we cannot "exclude the possibility of a prior phase of existence" (Silk 2001, 63), it is possible that the universe has cycled through oscillations, perhaps infinitely, so that Big Bangs occurred not once but an infinite number of times in the past and will do so in the future.
In a prior phase of research, we developed a conceptual framework of disability from the perspective of adults living with HIV.
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There were no serious AEs associated with VM202 treatment either in this study or in a prior phase I/II of DPN, 33 and the plasmid was similarly well tolerated in a study of critical limb ischemia.
A prior phase 1 study (9904) of TAS-106 monotherapy in solid tumor patients established the recommended dose of TAS-106 as 6.85 mg/m over 24 h as continuous infusion on day 1 of each 3-week cycle [ 17].
With a common SD of 0.75% based on the results of a prior Phase 2 study (unpublished data), 49 patients were needed per group to show superiority of tofogliflozin over placebo at a power of 90% and two-sided P < 0.05.
Within the editorial, Angus and Crowther also challenge the decision to predominantly target patients with elevated INRs, this decision having been based upon analysis of a prior phase 2 trial.
All participants with NF1 who were not involved in prior phases of instrument development, were encouraged to fill out the surveys.
Discussions concerning the progress made by incorporating strategies identified in the prior phases of the project were shared among the group.
However, a larger number of children were involved in the prior phase (identification of potential items through semi-structured interviews) [ 12].
Results of the prior Phase 1a trial of RiVax were published in the journal Proceedings of the National Academy of Science of the USA.
38 The study itself represented somewhat of a paradigm shift, given the absence of prior phase II studies assessing cabazitaxel specifically in the setting of prostate cancer.
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