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The study followed RA patients who failed at least one disease-modifying antirheumatic drug (DMARD) who were enrolled in a prior phase I/II dose-ranging trial.
Some have suggested that since we cannot "exclude the possibility of a prior phase of existence" (Silk 2001, 63), it is possible that the universe has cycled through oscillations, perhaps infinitely, so that Big Bangs occurred not once but an infinite number of times in the past and will do so in the future.
A prior phase I study combined oxaliplatin, protracted infusion 5FU and radiation in a preoperative setting (Khushalani et al, 2002).
In a prior phase of research, we developed a conceptual framework of disability from the perspective of adults living with HIV.
Within the editorial, Angus and Crowther also challenge the decision to predominantly target patients with elevated INRs, this decision having been based upon analysis of a prior phase 2 trial.
4 A prior phase 1, open‐label, dose‐escalation study assessed the maximum tolerated dose (MTD) of pomalidomide in patients with MM refractory to ≥2 lines of therapy or relapsing after previous therapy.
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The dose titration monitoring plan was different than any prior Phase 3 trial of vasopressin antagonists.
These were: (i) words encountered in a prior study phase (studied words), (ii) words presented at test for the first time (new words), and (iii) new words repeated after a lag of 7 9 intervening words (repeated test words).
In the episodic task participants indicated the screen location where words had been shown in a prior study phase (left/right/new); whereas in the perceptual task they indicated the current screen location of the word (top/middle/bottom).
Bubonic plague progresses rapidly to a life-threatening septicemia, but septicemia without a prior bubonic phase (primary septicemic plague), may also result from direct injection of plague bacilli into a blood vessel during the flea bloodmeal [2].
In a prior randomised phase III study in this setting (EFECT) no significant difference was observed between fulvestrant and exemestane, with a median progression-free survival of only 3 months [ 2].
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