Sentence examples for a principal problem is from inspiring English sources

A principal problem is the typical simultaneous activation of pathways activated by Ca2+ store depletion and by second messenger mechanisms such as generation or depletion of lipid mediators.

While moving in itself is a traumatic event as everyone knows, my principal problem is books.

The principal problem is TCA, or 2,4,6-trichloro anisole, a moldy-smelling compound caused by the action of chlorine on cork bark in a cleaning process.

The principal problem is that it doesn't have the bandwidth to process a lot of current high-quality downlink material from surveillance aircraft.

Far from "a noble act to impose discipline on American schools", the No Child Left Behind Act has in fact transformed American education from a place where broad learning has been replaced with a very narrowly focused "teach to the test" mentality.There are a number of other flaws with the No Child Left Behind Act, but the principal problem is that is assumes educators are not doing all they can.

"The principal problem is our schools.

The principal problem is those working parents simply do not earn enough to escape poverty.

The principal problem is that almost all oceanic crust older than about 200 million years has been obliterated by subduction.

"Pemex's principal problem is corruption, and that is not something that was brought even up in the government's diagnostic report," Mr. López Obrador said in the interview.

The principal problem is that it is too broad in scope.

The principal problem is that it negatively affects the long-term survival of the SEP.