Sentence examples for a principal problem however from inspiring English sources

A principal problem, however, is to obtain experimental data for each of these candidates, such as the full-length RNA sequence and its function.

In this context, mechanical ventilation (MV) is cornerstone; however, ventilator-induced lung injury (VILI) remains a principal problem, with an impact on patient outcome [4].

However, this does not provide us with a principal problem since the division into admission frequency classes (patient view) is along the lines of identified and distinct risk classes for which adjustment is clearly needed.

A principal problem of insurance risk theory is to find the probability of ultimate ruin.

The theory of contracts refers to this problem as a principal-agent problem; however, due to the complexity of the problem, it is necessary to recreate a dynamic interaction between the principal (i.e., the public entity) and the agent (i.e., the private entity) while including the monitoring of the infrastructure performance as an essential part of the interaction.

The United States poses a different problem, however.

There was a slight problem, however.

There is a big problem, however.

Apathy is a huge problem, however.

They have a little problem, however.

There was a big problem, however.