Sentence examples for a principal pathogenic factor from inspiring English sources

While there has been significant progress in the understanding of SLE genetics, which includes mapping of multiple SLE susceptibility loci/genes in the human and murine genome, to date no single or combination of structural gene defect has been identified as a principal pathogenic factor in inducing SLE [1], [2], [3].

We next wished to confirm these data in a second group of patients with the principal pathogenic factor being beta cell destruction.

Helicobacter pylori is the principal pathogenic factor in gastritis, peptic ulcer, and even gastric cancer and mucosa-associated lymphoid tumors [ 1, 2].

The expression of HIF-1α was analyzed in the context of the hypoxia level (as evaluated by pimonidazole staining), which is an established pathogenic factor for DN and the principal regulator of HIF.

Autoimmunity has long been proposed as a possible pathogenic factor for HaNDL [4].

Increased levels of reactive oxygen species (ROS) are a crucial pathogenic factor of osteoporosis.

Oxidative stress is a crucial pathogenic factor in the development of osteoporosis.

Reactive oxygen species (ROS) are a significant pathogenic factor of osteoporosis.

TNF-α is a key pathogenic factor in inflammatory arthritis.

This is a new pathogenic factor that needs further investigation.

NGAL may therefore be a crucial pathogenic factor and also a therapeutic target of RA.