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The phrase "a principal difference is that" is correct and usable in written English.
It can be used to highlight a key distinction between two or more subjects or ideas.
Example: "When comparing the two theories, a principal difference is that one emphasizes individual behavior while the other focuses on societal influences."
Alternatives: "a key difference is that" or "a major distinction is that".
Exact(1)
While there are some similarities among MDSCs (both PMN-MDSCs and Mo-MDSCs), neutrophils, and inflammatory monocytes, a principal difference is that PMN-MDSCs and Mo-MDSCs suppress T cell proliferation but neutrophils and inflammatory monocytes do not (Damuzzo et al., 2015; Gabrilovich et al., 2012).
Similar(59)
Of course, our approach is a generalization also, but it is a generalization on dimension space, and the principal difference is that we do not divide the cone, and it is treated as an emergent thing.
Mirella Otten, principal of L'Ecole des Petits, a French nursery in south-west London for three- to six-year-olds, says the principal difference is that English nurseries have a "gentler pace and are less like schools, but everything needs to be written up".
The principal difference is that I am married with two children.
The principal difference is that stamping requires force, while molding does not.
The principal difference is that the chip also contains integrated microcircuitry required to transfer the detected signal along a row of discrete picture elements (or pixels) and thereby scan a celestial object or objects very rapidly.
The principal difference is that the rule that board plans to propose would limit the initial write-down to the losses expected during the first year the loan was outstanding, rather than over its entire life.
The principal difference is that, unlike true clathrates where the guest molecules are not physically bonded within the water structure, in semiclathrate hydrates, the host/guest molecules of TBAB may form the part of the water lattice (host) as well as occupy cages (guest) along with the gas molecules [7, 8, 9, 10].
The principal difference is that relative warps are coordinate distances of shape variation derived through Procrustes superimposition of specimens [54], [55] and not measured variables, and that the variance captured by the relative warps is therefore related to differences in shape and not linear measurements.
The principal difference is that combinations are recovered using classes defined by expression similarity.
The principal difference is that the sample phase (Trial 0) immediately prior to the first trial involves a novel object paired with a highly familiar item from pretraining, for example, a wooden block.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com