Exact(1)
Assuming a primordial sequence of the type.RNYRNYRNY.., frame-shift reading mistranslations in the 2nd and 3rd reading frames produced sequences of the type.NYRNYR.., and.YRNYRN.., respectively.
Similar(59)
Hence the 59 residue repeat likely derives from gene duplication of a primordial module sequence.
Comparison of the different protein sequences revealed that one of the two mutations observed in the folding optimized protein (N32D) reverts an asparagine residue in protein 18-19 back to the aspartic acid residue present in the primordial sequence.
First, the smooth surface of the mountainous structure from the foot to at least a relative fitness of 0.4 means that it is possible for most random or primordial sequences to evolve with relative ease up to the middle region of the fitness landscape by adaptive walking with only single substitutions.
The introns-early theory predicts that at least some of the extant eukaryotic introns are direct descendants of the primordial sequences in the LUCA [ 2- 5].
Perhaps this monodomain Arg(A -like sequence is A -likerdial enzyme originally recruited from an ancient pool of N-acetyltransequence (see Fis. 7 for a primordialvolutionary schenzyme
A different type of recombination event led to the lenF-1 clade, with len-motifs of the lenC lineage replacing the homologous sequences of a primordial lenF gene.
The percussion writing begins with a primordial scratching and moves first to an ambitious sequence of bongo cross-rhythms, some contrapuntal bashing at a trap set (a quotation from drum figure in Led Zeppelin's "When the Levee Breaks" easily fits the "Gotterdammerung" imagery) and a tour of other corners of a vast arsenal of instruments.
Forterre even assumes eukaryotes are a primordial lineage, as a consequence of taking the sequence tree too literally.
In addition, a primordial germ cell-derived partial chicken EST (GenBank accession DR410403) included sequence with clear homology to the 3′ part of Exon 1 from non-avian POU2 orthologs.
A putative herpes virus recombinase pR1 homologous to RAG-1 with additional N-terminal amino acid sequences in both proteins [17] would also provide amino terminal protein sequences present in RAG-1, and bind to a primordial RAG-2 protein (pR2) co-expressed in somatic cells prior to the origins of the acquired immune system in the sea urchin.
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