Exact(32)
Predicting the secondary structure of proteins from a primary sequence alone has been variously approached from either a classification or a generative model perspective.
As mTRPML1 resembles human TRPML1 in a primary sequence similarity up to 91% (Fig. S3), we performed a direct and rigid body fitting of the human crystallographic PMD structure into the cryo-EM density map (Li et al., 2017).
From this we conclude that CAPN3 indeed recognizes a primary sequence motif.
In this investigation we define a primary sequence motif underlying CAPN3 substrate cleavage.
We have provided evidence that CAPN3 recognizes a primary sequence motif in its substrates.
In order to define ECO, we assume four residues i, k, m, and j along a primary sequence.
Similar(28)
Even with a correct primary sequence, an improper translation elongation rate in a heterologous expression system is an important cause of misfolding.
By regarding a DNA primary sequence as a random process in time and defining the nucleotides' random distribution functions in three ways based on chemical structures they proposed two methods to measure their similarities.
Thus, given a protein primary sequence, we can design a matrix-based protein descriptor to represent it, which is capable of facilitating PPIs detections.
The newly identified putative homolog is used to query a structural database to identify proteins with a similar primary sequence.
Consequently, DSRM-containing proteins bind RNA based essentially on structural features and not on primary sequences although, in some cases, a specific primary sequence can influence binding by inducing a particular RNA secondary structure [ 6, 7].
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