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A primary origin for these inclusions was inferred based on their distributions as three dimensional groups or occurrence as comparatively large, isolated inclusions.
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These observations provide evidence for a primary origin of the observed remanences.
ISOLATE will be an invaluable tool for exploring new, uncharacterized cancers of unknown primary origin for which little expression data are available, or clinically ambiguous samples for which more traditional models cannot classify with high accuracy.
The primary origins for the outperformance of W2N over WO3-x in acid aqueous electrolytes are uncovered by electrochemical analysis, simulation work and in-situ transmission electron microscope (TEM).
According to the authors, these findings support a primary inflammatory origin for ALs [ 22].
The thyroid area with compact folicular structure presents intense immunoreactivity for thyroglobulin (e) Open image in new window Fig. 2 a d Metastatic ovarian carcinoid of unknown primary origin in a 23-year-old female complaining of pelvic pain and amenorrhoea.
The absence of after-discharges at the implanted electrodes and the agreement with previous literature on insular function are further arguments for a primary insular origin of the reported responses.
Endoscopy, colonoscopy, abdominopelvicsonography and imaging studies were negative for primary origin.
ISOLATE, unlike previous methods for classifying cancers of unknown primary origin, is an unsupervised classification algorithm, which provides it with several inherent advantages.
Cancer of unknown primary origin presents a clinical challenge as the origin of tumour tissue is crucial for selecting proper treatment plan.
Multiple miRNA predictors have been developed to classify differentiation stages of cancers; a useful tool, especially for cancers of unknown primary origin [ 10].
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