The phrase "a primary mediator of" is correct and usable in written English.
It can be used when discussing the main agent or factor that facilitates or influences a particular process or relationship.
Example: "In the study, we found that social support acts as a primary mediator of stress reduction among participants."
Alternatives: "a key facilitator of" or "a main agent of".
In this study, we demonstrated that NKDCs, functioning as immunostimulatory DCs, could be a primary mediator of the α-GC-mediated immune response.
It also supports the biological role for HBP as a primary mediator of vascular leakage, an important pathophysiological mechanism in septic shock.
α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor is a primary mediator of fast glutamatergic excitatory signaling in the brain and has been implicated in diverse neuropsychiatric diseases.
Prophages are a primary mediator of GAS intra- and inter-serotype differences in virulence factor content [80].
The emerging idea is that TNFα is not a primary mediator of NASH but influences its development [9], [10], [12].
Based on work in cultured cells, SHP-2 is thought to be a primary mediator of cytoskeletal disruption induced by CagA [24].
Thus, Gpr1 does not appear to serve as a primary mediator in the acute response of cells to glucose addition.
4 The function of VEGFR-1 is less well characterized but it is believed that VEGFR-1 has both vascular and nonvascular functions, and it is expressed in tumor cells, as well as monocytes and macrophages, 4, 6, 17, 21 whereas VEGFR-2 is believed to be the primary mediator of VEGF-A action on angiogenesis and increased vascular permeability.
Although we cannot exclude with certainty the role of t-Ag and other T'- proteins, based upon our results it is reasonable to speculate that T-Ag may be the primary mediator of a metastatic phenotype in colon cancer cells, and some of these effects may directly or indirectly be influenced by the activation of AKT/MAPK pathways [44], [45].
A recent report has indicated that VEGF-C, the primary mediator of lymphangiogenesis, is a downstream factor regulated by SIRT1 [ 25].
We revised the Results and Discussion to better set up and then state our argument against an activation chain as the primary mediator of the grooming sequence.
