The phrase "a primary issue with" is correct and usable in written English.
You can use it when discussing a main problem or concern related to a specific topic or situation.
Example: "A primary issue with the current policy is its lack of clarity, which leads to confusion among employees."
Alternatives: "a major concern regarding" or "a key problem with".
A primary issue with TRISO fuel operation is the observed release of 110mAg from intact fuel particles.
Similarly, a primary issue with internal validity relates to model specification and ensuring that all relevant variables have been included in the model to support a thorough investigation of the hypothesized causal mechanism(s) and to make possible ruling out alternative hypotheses for an estimated effect.
A primary issue with the Arizona-style attempt to secede is its blatant hypocrisy, as the rejected Baja Arizona amendment illustrates.
Low plasma fibrinogen levels are a primary issue with haemodilution related to the use of volume expanders, and are predictive of bleeding risk and need for transfusion of allogeneic blood products.
However, the primary issue with these approaches is that many disastrous earthquakes do not reappear on previously identified faults (Lee et al. 2011).
However, the primary issue with AR modeling is that the accuracy of the spectral estimate is highly dependent on the selected model order.
At any rate, it looks like a nice phone, and the improvements over the E71 are welcome, even if they don't fix my primary issue with the phone (the interface).
The primary issue with ensemble displays is that visual crowding may occur, which happens when ensemble members are plotted too closely together and cannot be easily differentiated, increasing difficulty in interpretation.
The primary issue with the covered ponds at the abattoir was the build-up of fat/crust that prevented the accurate measurement of biogas and effective use of the cover.
