The phrase "a primary hit" is correct and usable in written English.
It can be used in contexts such as data analysis, marketing, or research to refer to the most significant or initial result from a search or study.
Example: "In our analysis, we found that the advertisement generated a primary hit among the target demographic, leading to increased engagement."
Alternatives: "a main result" or "a key finding."
Reporter screening strains have been constructed for three gene targets (gyrA, glmU, secA), and one (gyrA) has been applied to 68,000 compounds resulting in a primary hit rate of 0.5% and a confirmed hit rate of 0.06%, including several fluoroquinolones.
Here, we demonstrate the rapid improvement of a primary hit against matrix metalloproteinase-14 using this approach.
All scores within the project can be displayed so that the user can see the results of any secondary analysis of the gene and make an informed decision about its significance as a primary hit.
Through biophysical and structural characterization, we reveal that the trypanosome and human UAP differ in the order of sequential substrate binding and that a primary hit compound is a species-specific UTP-competitive allosteric inhibitor of TbUAP.
A primary hit group of Drosophila genes were identified that prevent park translocation and other aspects of Pink1-related mitochondrial homeostasis, including alterations in mitochondrial morphology and perinuclear aggregation of mitochondria.
The initial view that considered steatosis as a primary hit and gut-derived endotoxin as the second hit determining progression of the disease is now followed by a more complex model where many hits may act in parallel [ 40].
This issue has been successfully solved with a new filtering function that excludes secondary hits depending on extension and similarity of the overlap relative to a better primary hit according to an adjustable threshold preset to 30% (Fig. 3).
The 19F NMR screening yielded a high primary hit rate of binders to the ERK2 ATP-binding pocket compared with the rate for the SPR screening.
The initial screening resulted in the selection of 201 potential inhibitors of the E6 E6AP interaction (a 0.23% primary hit rate) that were further investigated in follow-up studies.
A SBDD approach to the GSK-3β and CDK5 proteins was applied to all primary hits, and 5 selective inhibitors were identified for GSK-3β.
The primary hit, a thiazolidenebenzenesulfonamide derivative, possessed good activity.
