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Progressive asymmetric degeneration of nigrostriatal dopaminergic innervation is a primary hallmark of Parkinson's disease.
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For Hausman, the primary hallmark of transsexuality is the sheer demand for transsexual surgeries through which transsexual subjects are constituted as such (1995, 110).
Rapid and uncontrolled proliferation is the primary hallmark of cancer and underlies various other characteristics of tumours, e.g. angiogenesis and altered metabolic profiles [ 34].
This is of considerable importance as the primary hallmark of sickle cell disease is the ability of RBCs to abnormally interact with endothelial cells, leukocytes and platelets, and these cell-cell interactions are mediated through activation of RBC surface adhesion receptors.
Dr. Morrison sketched a genetic pedigree as she listened to the Abeyta family discuss whether various aunts, uncles and cousins had symptoms of ptosis (eyelid drop), dysphagia (trouble swallowing) or hip and shoulder weakness, the primary hallmarks of OPMD.
One of the primary hallmarks of psychosis is the state of being delusional.
Along with NFTs, Aβ plaques are considered a primary pathological hallmark of AD and Aβ load is often used as a marker of AD severity [ 1, 35].
ALS is a fatal, neurodegenerative disease in which the primary hallmark is the selective degeneration of upper motor neurons and lower spinal motor neurons.
Misfolded α-synuclein (aSyn) is the main protein component of Lewy bodies (LBs) – the primary pathological hallmark of PD – and aSyn has also been genetically linked to both familial and idiopathic forms of PD.
The primary histopathological hallmark of GD is the formation and accumulation of lipid-engorged macrophages known as Gaucher cells leading to visceral organomegaly.
The primary pathologic hallmark of gout is neutrophil influx into the joint fluid [ 3], which is consistent with IL-1 and tumor necrosis factor-α-induced activation of endothelium with resulting expression of adhesion molecules for leukocytes [ 11, 12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com