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A primary difficulty is that the soybean genome is 4 10 times larger than the model plants Arabidopsis thaliana, Medicago truncatulata or Lotus japonicus.
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The primary difficulty is making use of a potentially infinite set of solutions.
The primary difficulty is to determine which policies should be removed, and the resolution addresses the inconsistency most effectively.
The primary difficulty is how to create the asymmetry such that each participant has a unique secret with which to authenticate its messages, while allowing all the receivers the capability for validation.
The primary difficulty is that the AHR regulates – either directly or indirectly – hundreds of genes, often in tissue-specific patterns [ 17- 24].
As at Darwin, Herring's primary difficulty was logistics.
Morgan felt that the primary difficulty was in moving the story forward while still leaving room to recap what had happened previously for the benefit of viewers who had not seen the first episode; this led to the use of the courtroom scene as a means to repeat any necessary information.
Our patients' primary difficulties were antisocial behavior, histories of serious violence including homicide, and levels of risk such that they necessitated high-security hospital treatment.
A primary difficulty in bioinformatics is integrating erratically formatted data from different resources [17], [18].
A primary difficulty with such a definition is that its sensitivity to factors known collectively as "bone quality" has not been clarified, and it is tempting to attribute the diagnostic ambiguities of bone mineral density (BMD) measurements to their failure to account for these features.
A primary difficulty in using a data set of the distribution of volcanic vents is determination of independence of events.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com