The phrase "a primary defect" is correct and usable in written English.
It can be used to describe a main or significant flaw in a system, product, or process.
Example: "The engineers identified a primary defect in the software that caused frequent crashes."
Alternatives: "a major flaw" or "a key issue."
Further studies should investigate whether the defective PGC-1α expression is a primary defect or whether it is secondary to insulin resistance or reversible lipotoxicity.
Further, it remains unknown whether the defective IL-17 and IL-22 production was the consequence of a primary defect (e.g. genetic) or was secondary to a predisposing factor of the Aspergillus SBO patients (e.g. the antifungal treatment).
Accidental hypothermia concerns a body core temperature of less than 35 °C without a primary defect in the thermoregulatory system.
This suggests that a primary defect in CFTR expression is not the root cause of neutrophilic inflammation in these disease contexts.
A primary defect of steroidogenesis resulting in increased ovarian and adrenal androgen production may be responsible for polycystic ovary syndrome, at least in some patients.
The depressed palea1 (dp1) mutants show a primary defect in the main structure of palea, implying that palea is a fusion between the main structure and marginal tissues on both sides.
Third, Snord116del mice may have a primary defect in another brain region.
However, a primary defect within the cellular mechanisms regulating keratinocyte maturation is also conceivable [9].
These results indicate that neurotransmitter metabolism might be a primary defect in the smn mutant and thus in SMA pathology.
Few studies have addressed barrier formation in mice with a primary defect in GC affecting meiotic progression.
A primary defect in the decidual response may further explain why the incidence of miscarriage drops dramatically after 12 weeks gestation [2].
