In addition, primary coordination of the inpatient service and case assignments are under the auspice of the Chief Resident, which also ensures the residents are able to have the experience and oversight of the cases needed for their core training.
In structures (1) and (2) the primary coordination of the Cu II) ion is unchanged, even in presence of different chelating N,N-ligands.
The protein environment is one of the, if not the, most important factors determining the reduction potential in Fe S proteins because the general geometry and primary coordination of iron are very similar in this family of proteins.
Maquettes are effective synthetic analogs for metal ion binding sites, allowing for a facile modification of the primary coordination sphere of iron sulfur clusters.
The Zn2+-binding site in the designed receptor is based on a four-coordinate, tetrahedral primary coordination sphere consisting of histidines and glutamates.
As with other redox-active metal centers, the primary coordination sphere of a metal ion plays an important role in its redox properties.
In completing the primary coordination sphere of the iron, cytochromes typically use a combination of nitrogen and sulfur ligations from histidine or methionine side chains, respectively; terminal amine ligation has also been observed.
The primary coordination sphere of germanium is still pyramidal for [GeI3]−, but the secondary interactions to neighbouring iodides result in an overall six-coordinate distorted octahedron at germanium.
Satisfaction of the primary coordination sphere for a given metal is sufficient to introduce catalytic activity and a given structure may catalyze different reactions dependent on the identity of the incorporated metal.
The photophysical properties of these traditionally underperforming luminescent complexes can be dramatically modified in a qualitatively predictable fashion through ligand design, the use of bichromophoric ligands, and by reconstitution of the primary coordination sphere.
The affinity for the unfolded state is dependent on the placement of the primary coordination sphere residues within the linear protein sequence.
