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We have previously demonstrated that co-mutation analysis can be compromised by the pooled analysis of phenotypically and genotypically distinct groups, which creates false positives from genes that are co-mutated or mutually exclusive due to a primary association with tumor subtype rather than other mutations6.
A comparison of magnetization values and geologic structure seems to indicate a primary association between them (Figs. 3 5).
Interestingly, initial findings associated the HLA class I A*01 and B*08 genes with susceptibility to celiac disease (CD), though further analysis showed a primary association with alleles encoding for HLA DQ2/8 molecules [15].
Although the term homa sometimes has other implications in the wider taxonomy of disease, homa and homa kali always carried a primary association with mwili joto or 'hot body' (also: mwili kuchemka, 'boiling body').
We have shown here that this association is probably due to a primary association with positivity for ZnT8A and not with IA-2A positivity directly.
However, there are conflicting data regarding a primary association between being African-American and higher serum urate concentrations when compared to other races.
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The focus on TM4 is justified by a number of published experimental studies on several GPCRs (9− 20), including our early correlated mutation analyses of opioid receptor sequences (21, 22), suggesting a direct primary association of lipid-exposed surfaces of these helices.
Conditional logistic regression analysis performed on the six most significant genotyped markers from the extended case control study (which focused on coding SNPs and potential splice-site variants) did not allow us to identify an obvious primary association.
Because the appropriateness of antibiotics, the absence of a positive culture, and DNR status could have an important effect on the primary association of interest, a sensitivity analyses were performed.
The primary association was defined from a population of 83 African American NS cases compared with 1645 healthy controls.
Furthermore, alterations of the ECM within the juxtacanalicular (JXT) portion of the TM have been found to be a primary pathophysiologic association with POAG.
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