This is consistent with a previous study utilizing active immunization where epitope mapping indicated that the best results in terms of reducing a-syn was observed with antibodies that preferentially recognize the CT of a-syn [17].
Findings from a previous study utilizing cryosections and in vitro data also support the existence of multiple sources of cortical interneuron progenitors in the developing human brain [ 137].
Fibrin is known to induce IL-8 expression in human umbilical vein endothelial cells (HUVECs) [ 69] and a relatively high expression of IL-8 was found in a previous study utilizing primary human dermal fibroblasts on the fibrin matrix [ 68].
An analysis of Arabidopsis expression profiling data obtained from a previous study utilizing a tiling array [ 3] indicated that the expression of the TAS1/2/3 family was downregulated under drought and high-salinity stress).
PIP2-triggered kinase activation in the absence of DAG was first described in a previous study utilizing a higher PIP2 density (5 mol %) that fully activated the kinase, suggesting that high PIP2 densities may obviate DAG regulation.
A previous study utilizing a trial that allowed free-moving reciprocal social investigation between test and partner animals demonstrated that AVPR1A was important in establishing normal social interactions (Egashira et al., 2007).
