In a previous study using a differential exposure setting with 211At, we hypothesized that thyroid-dependent systemic factors have an impact on target tissue responses [11].
In a previous study, using a pair of low grade/high grade mouse SCC cell lines derived from the same primary tumor (CC4B/CC4A cells), we identified by differential display a gene product that was lost in invasive tumor cells [3].
One previous study, using a neonatal rat hypoxia-preconditioning model, showed differential molecular responses in neocortex, hippocampus, striatum and thalamus, even though HP produced similar protection in these regions [ 15].
Here, we pursued the previous studies using RyR1 RyR2 chimera channels to improve our understanding of the structural basis of differential regulation of RyR1 and RyR2 by Ca2+ and Mg2+.
Previous studies using gene expression approaches to obtain information on the differential expression within this gene family have characterised Mal d 1.02 as the most expressed isoallergen gene [ 17- 20].
Previous studies using laser capture microdissection (LCM) have examined differential gene expression between stromal samples, either prostate stroma relative to bladder stroma [ 11] or reactive tumor stroma relative to normal stroma [ 12].
This lack of any significant differential removal of the AP sites agrees with previous studies using free DNA [49], [51], [54], [55], [56], [57].
Comparison between our results and the previous one revealed 1.5-fold differential expressed genes identified in this study using the same criteria (FDR ≤ 5% and fold change ≥1.5).
"Previous studies used different diagnostic criteria.
Previous studies used aggregate data.
