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Furthermore, they support a previous notion on the threshold levels of β-catenin and a contextual dependency of β-catenin function.
It is notable that, except hsa-miR-125b, the other nine miRNAs were all predicted to be 'ACTIVATED' by MYC, and this seems contradictory to a previous notion that 'widespread microRNA REPRESSION by Myc contributes to tumorigenesis' [ 42].
However, against a previous notion, in the reeler background ectopic reelin did partly rescue cortical lamination, specifically in the cell population positioned above, but not that one below, an ectopic subplate (Fig. 3C,D,F).
This distribution is in agreement with a previous notion that essential genes, and especially highly expressed such genes, show a clear tendency to locate near the origin of replication in E. coli [ 29].
This observation suggests that transcription initiation and reinitiation are noncooperative and independent, which is somewhat inconsistent with a previous notion that the scaffold of transcription initiation factors remains bound to the promoter and reinitiates multiple rounds of transcription at the end of each abortive event.
Interestingly, we noticed a positive association between both IL-6 and IL-10 which accords with a previous notion [ 33] and could be attributed to the fact that secretion of both interleukins is stimulated by the same cytokines such as TNF-α [ 34, 35].
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I lived with nine Catholics, and from the love of my community, I discovered a love that confounded any previous notions I'd had of religious people, a love that taught me what God is.
— threaten to capsize their marriage and destroy any previous notions of what constitutes an acceptable life.
The scale of the possible tsunami trumps all previous notions of the risks facing the town.
There are a handful of surfers, most of them Hawaiian, who on certain serendipitous days manage to ride very big waves in ways that expand all previous notions of what is possible.
This finding not only lends a support but also offers a molecular mechanism for the previous notion that Akt activation can occur in a PI3K-independent manner [ 47– 47].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com