The prevalent effect of riboflavin was the reduction of migraine frequency (68.4% responders, 18.4% semi-responders, particularly among younger patients, under 12 years: 91.7% responders).
Immunohistochemical analysis supported the prevalent effect of STZ- Timp3 −/− on nuclear FoxO1, both in the glomerular and tubular compartments (Fig 3C, D and Supporting Information Fig S13).
In chronic inflammatory disease states, such as rheumatoid arthritis (RA), the prevalent effect of activated CD4+ T cells is stimulatory towards the formation and activity of osteoclasts, resulting in bone loss and degradation of joint architecture [ 4].
In animal cells, the prevalent effect of miRNAs is translational repression of the target mRNA without affecting the levels of mRNA itself, although the mechanisms that induce target mRNA degradation by RNA induced silencing complex mediated cleavage [2] or rapid deadenylation [3] and decapping [4] have also been reported.
While most of the prevalent effects of diabetes are long-term in nature, the disease can also have devastating effects in the short-term if not managed correctly.
Sexual dysfunction has only recently been recognized as a highly prevalent side effect of adjuvant aromatase inhibitor (AI) therapy for breast cancer.
Stimulation of cancer growth, rather than inhibition by the immune reaction, is seemingly the prevalent effect in the animal of origin (the autochthonous animal).
They impair tumour progression at different levels, with the most prevalent effects being the inhibition of cell proliferation by apoptosis, cell cycle arrest, and autophagy.
Insomnia is a prevalent and persistent side effect of cancer, which if left unaddressed, can be unremitting and negatively influence physical and mental well-being.
15 According to their mechanism of action and their prevalent effects on osteoblasts and/or osteoclasts (cells involved, respectively, in bone formation and bone resorption) all the above compounds are generally grouped into two major classes (Table 2): antiresorptive (inhibiting bone resorption) or anabolic (stimulating bone formation) agents.
