Recently, an innovative approach based on inhibitors of the mutated BRAF gene (which represents the most prevalent alteration in melanoma patients) appears very promising from the clinical point of view.
In paediatric PTC (spontaneous and radio-induced), RET/PTC rearrangements are the most prevalent alteration (60 80%), while BRAF point mutation is only observed in about 4% of the cases (Nikiforov, 2002; Xing, 2005).
However, one of the most dramatic and prevalent alterations in plant genetics has occurred through artificial selection of corn.
Other prevalent alterations included epigenetic silencing of the direct repair genes EXO5, MGMT, and ALKBH3 in ∼20% of samples.
Missense mutations are the most prevalent alterations (75%) located mainly within the DNA binding domain.
In all muscle biopsies the prevalent alterations were myopathic atrophy and hypertrophy, increased number of internalized myonuclei, necrosis and regeneration, and fibro-fatty substitution.
Microarray analysis identified among the most prevalent alterations in cervical tumors and cell lines the amplification of the RBP1- Retinoletinol binding protein 1 and 2, 58.8%) and Tp63 (52.9% of the samples) genes, located at 3q21-q22 and 3q27-q29, respectively.
This chromosomal rearrangement is a highly prevalent oncogenic alteration in prostate tumor cells and leads to an aberrant expression of the ERG proto-oncogene, important for early prostate carcinogenesis [ 57].
For decades, focusing on cell size alterations has been a prevalent criterion for identifying START regulators (Carter and Sudbery 1980; Sudbery et al. 1980; Jorgensen et al. 2002; Zhang et al. 2002).
"It's a prevalent problem.
His is a prevalent view these days.
