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A framework for the present trial was a previous trial in osteoarthritis with the vincaria component alone [ 25], administered at a three-fold lower dose (100 mg).
The study protocol presented here provides an overview of the present trial including a description of the methods, design, and current status of the trial as well as a discussion of the possible implications that may arise from the findings.
A limitation of the present trial was the reduced sample size and consequent low power to detect differences between groups.
In three patients not suitable for inclusion in the present trial a diagnosis of depression was made according to the DSM-IV criteria.
In contrast with previous trials of B vitamins, the present trial used a lower dose and a more naturally occurring formulation of folic acid.
Patients enrolled in the present trial had a severe transfusion need, reflected in a high median transfusion demand before inclusion and a high median ferritin level.
The procedures developed in the present trial are a viable means by which to conduct such a study.
The present trial investigates an escalation strategy where patients start with a well tolerated single-agent chemotherapy (capecitabine) combined with bevacizumab.
The present trial is a phase IIb efficacy assessment trial.
The present trial is a response to this guidance.
16 The present trial provides a more robust evidence base to explore these issues.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com